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Fig. 4 Genetic rescue of the maternal cea mutant phenotype by sas-6 expression. Side views of live embryos at the 1000-cell stage (A–D, I–K) and animal views of fixed embryos labeled to detect β-catenin and DNA (E–H, L–N). Injection of mRNA coding for Sas-6L and Sas-6S results in a similar extent of rescue (panels B–D, F–H compare to panels A, E). Injection of mRNA coding for the mutated cea protein results in significant rescue (panels K, N; compare to panels I, L), which is nevertheless not as effective as the rescue conferred by wild-type mRNA injected in sibling embryos (J, M).
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Reprinted from Developmental Biology, 312(1), Yabe, T., Ge, X., and Pelegri, F., The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication, 44-60, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.