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Fig. S4 Injection of RNA encoding full-length Tfap2a into tfap2a/c deficient embryos efficiently rescued foxd3 expression in premigratory neural crest (pnc). (A–C) Dorsal views of flat-mounted embryos at 11 hpf, anterior to the left. foxd3 is expressed in pnc cells in A, a uninjected wild-type embryo, and this expression is absent in B, a tfap2aMO/cMO embryo. (C) In tfap2aMO/cMO embryo also co-injected with tfap2a and lacZ mRNAs, foxd3 expression in pnc cells is visible on the injected side, marked by X-gal stain (light blue) (36 of 43 tfap2a mRNA injected tfap2aMO/cMO embryos). Scale bars: 100 μm.
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Reprinted from Developmental Biology, 304(1), Li, W., and Cornell, R.A., Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos, 338-354, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.