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Fig. 1 β4GalT1 is a zebrafish ortholog of mammalian β4GalT1. β4GalT1 was identified by in silico homology to human β4GalT1 and was cloned from a 48 h total RNA library. (A) Alignment of β4GalT1 from zebrafish (dr/red) human (h) and mouse (mm). Identical residues are shaded. Predicted catalytic residues are boxed in red, and cysteines used to align the sequences are boxed in blue. (B) Unrooted phylogenetic tree demonstrating the relationship between zebrafish β4GalT1 (red) and human (green) and mouse (blue) β4GalT1 and β4GalT2, suggesting an ancestral relationship.
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Reprinted from Developmental Biology, 297(2), Machingo, Q.J., Fritz, A., and Shur, B.D., A beta1,4-galactosyltransferase is required for convergent extension movements in zebrafish, 471-482, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.