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Fig. 2 Block of Notch signalling decreases the number of exocrine cells in the pancreas. In situ hybridizations showing reduction of mnr2a (A–D), ptf1a (E–H) and trypsin (I–L) expression in mib mutants (C, G, K) and DAPT-treated embryos (D, H, L). The pancreatic area is depicted. Embryos in panels A, E, I and B, F, J should be compared with embryos in panels C, G, K and D, H, L, respectively. Embryos have been hybridized at 72 hpf and are presented in ventral view with anterior to the left. Scale bar in panel A is 50 μm.
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Reprinted from Developmental Biology, 301(1), Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F., Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish, 192-204, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.