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Fig. 6 Expression of late endothelial markers in the region of forming venous plexus is reduced in HS6ST-2 morphants. Expression of flk-1 as shown by whole-mount in situ hybridization in a wild-type embryo (A) and a HS6ST-2 MO-injected embryo (B) at 24 hpf. Normal expression of flk-1 is observed in HS6ST-2 MO-injected embryos at 24 hpf (n = 19). However, at 30 hpf, the expression domain of the late endothelial marker, tie-1 (D; 81% ± 8%, n = 40, ±SEM) is reduced in the region of caudal vein (area indicated by brackets and arrowheads) in HS6ST-2 MO-injected embryos compared to wild-type embryos (C).
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Reprinted from Developmental Biology, 284(2), Chen, E., Stringer, S.E., Rusch, M.A., Selleck, S.B., and Ekker, S.C., A unique role for 6-O sulfation modification in zebrafish vascular development, 364-376, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.