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Fig. S2 Overexpression of hdac1 in wildtype embryos causes brain and trunk defects. Injection of hdac1 RNA causes and enlargement of the forebrain (arrows) at moderate doses (B, compare to A). At high concentration hdac1 RNA causes loss of forebrain tissue and an expansion of midbrain (D, compare to C) accompanying severe loss of trunk tissues. wnt1 expression marks the posterior edge of the midbrain (arrow E) in uninjected wildtype embryos at 2 dpf. Embryos injected with hdac1 RNA display an antero-posterior expansion of wnt1 expression (arrows).
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Reprinted from Mechanisms of Development, 124(9-10), Nambiar, R.M., Ignatius, M.S., and Henion, P.D., Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration, 682-698, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.