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Fig. 2 The overall Trap230 loss-of-function phenotype. (A, D, G, H) WT, (B, E) tpd, (C) Trap230 morpholino-injected embryos. (A–E) Embryos at 3 dpf. (D, E) Methylene blue-stained transverse sections at the level of the pectoral fin buds (arrows and asterisks). (F) Trap230 MO-injected embryos lack the RT-PCR product amplified from exons 26 and 27, since intron 26 fails to be spliced out. (G, H) trap230 mRNA expression. (G) Four-cell stage, animal pole to the top. (H) Three-somite stage, lateral view, dorsal to the top, anterior to the left. MO: Trap230 morpholino injected.
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Reprinted from Developmental Biology, 296(1), Rau, M.J., Fischer, S., and Neumann, C.J., Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development, 83-93, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.