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Fig. 3 Both FurinA and FurinB function are required to activate Edn1 signaling. Flat mounts of Alcian-stained cartilages and bones at 5–6 dpf. (A) Wild-type, (B) furinA mutant, (C) furinA MO-injected larva, (D) furinB MO-injected larva, (E) furinB MO injected into furinA mutant, (F) low edn1 MO-injected larva, (G) edn1 mutant, and (H) dlx3b MO + dlx5a MO-injected larva. Wild-type DV joint regions are indicated with arrows in panel A. Fusions at joint regions are indicated with asterisks in panels B–H. Scale bar: 50 μm.
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Reprinted from Developmental Biology, 295(1), Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B., Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning, 194-205, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.