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Fig. 6 Ectopic PGCs are rescued from apoptosis by overexpression of Bcl2l. (A) Vasa-positive cells (arrows) and (B) rare TUNEL-positive cells (arrowheads) in dorsal trunk of igf1rb-MO/bcl2l mRNA co-injected embryo; (C; merged image) lack of colocalized Vasa and TUNEL signals (arrows, arrowheads) confirms absence of DNA fragmentation in ectopic PGCs (compare with Fig. 5, panels A–C). Magnification, 200x.
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Reprinted from Developmental Biology, 305(1), Schlueter, P.J., Sang, X., Duan, C., and Wood, A.W., Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival, 377-387, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.