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Fig. 4 Targeted knockdown of either IGF1R subtype results in increased apoptosis. In situ cell death (TUNEL) analyses of zebrafish embryos after injection with (A, D) control morpholinos; (B, E) IGF1Ra antisense morpholinos (igf1ra-MO); (C, F) IGF1Rb antisense morpholinos (igf1rb-MO). Embryos in upper panels are 18-somite stage embryos; embryos in lower panels are prim-5 stage embryos. Relative to control-MO-injected embryos (A, D), TUNEL-positive cells are more abundant in both igf1ra-MO- and igf1rb-MO-injected embryos, at both stages of development. Magnification, 100x.
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Reprinted from Developmental Biology, 305(1), Schlueter, P.J., Sang, X., Duan, C., and Wood, A.W., Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival, 377-387, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.