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Fig. S6 Tryptophane hydroxylase localize to the nk2.1+ region. (A-E) Apical views on the Platynereis forebrain, ventral to the bottom. E is a merged views of C and D. Arrowhead points at Platynereis tryptophan hydroxylase (Pdu-tph) positive (i.e. serotonergic) cells. (F-H) Correlation of serotonergic and nk2.1 cells in the fish hypothalamus. Arrowheads point at tph cell co-expressing nk2.1. Arrows point at cells not co-expressing nk2.1. Riboprobes and stages as indicated. e: epiphysis.
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Reprinted from Cell, 129(7), Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., and Arendt, D., Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution, 1389-1400, Copyright (2007) with permission from Elsevier. Full text @ Cell