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Fig. 1 Mutations affecting specification of endothelial precursors. (A–D) Epifluorescent micrographs of 36 hpf wild-type (A), clos5 mutant (B), mins202 mutant (C), and grcs635 mutant (D) embryos visualized by Tg(flk1:EGFP)s843 expression. Morphologically, grcs635 and mins202 mutant embryos show no obvious defects, but the number of endothelial cells appears significantly reduced (C and D), a reduction comparable to that seen in clos5 mutant embryos (B). White arrows point to region with Tg(flk1:EGFP)s843 positive endothelial cells are conspicuously missing.
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Reprinted from Developmental Biology, 307(1), Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y., A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos, 29-42, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.