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Fig. 2 Abnormal jogging and looping. (A) Jog reversal. Hearts that jog to the right (left panel, arrow points to the prospective atrium) always loop to the left (right panel). (B) Directionless jog. In no tail mutant embryos, the hearts fail to jog (arrowhead points to the midline) and may loop to left, right or remain straight. The heart is labeled with Nkx2.5 in 24hpf embryos and MF20 in 48hpf embryos. a, atrium; v, ventricle; L, embryo left.
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