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Fig. 7 Developmental expression pattern of npo. (A-F) Whole-mount in situ hybridization to npo at the indicated developmental stages. (A,B,D) Dorsal view demonstrates dynamic expression in the digestive organ primordia. Expression begins at about 48 hpf, peaks at 72 hpf, then recedes in an anterior to posterior wave around 84 hpf. (C) Right oblique view showing expression of npo in the exocrine pancreas at 72 hpf, but not in the pancreatic islet. (E,F) Lateral view showing brain and endoderm expression at 24 hpf, then branchial arch and endoderm expression at 60 hpf. l, liver; g, gut; p, pancreas; i, islet; ep, exocrine pancreas; en, endoderm; ba, branchial arches.