Gene
bmpr1ba
- ID
- ZDB-GENE-991208-8
- Name
- bone morphogenetic protein receptor, type IBa
- Symbol
- bmpr1ba Nomenclature History
- Previous Names
-
- BMPR-IB (1)
- bmpr1b
- BR1b
- alk6
- alk6tr
- zALK-6
- zgc:92220
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway and determination of dorsal identity. Predicted to localize to plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Is expressed in several structures, including anterior neural rod; nervous system; optic primordium; ovarian follicle; and pectoral fin musculature. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu129 (1 image)
- IMAGE:7158013 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acromesomelic dysplasia-3 | Alliance | Acromesomelic dysplasia 3 | 609441 |
| brachydactyly type A1D | Alliance | Brachydactyly, type A1, D | 616849 |
| brachydactyly type A2 | Alliance | Brachydactyly, type A2 | 112600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR003605 | GS domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | GS domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9W629
|
530 | ||||||||
|
UniProtKB:A0A8M9PJN6
|
498 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bmpr1ba-201
(1)
|
Ensembl | 1,900 nt | ||
| mRNA |
bmpr1ba-202
(1)
|
Ensembl | 2,265 nt |
Interactions and Pathways
Plasmids
No data available