Gene

men1

ID

ZDB-GENE-991110-12

Name

multiple endocrine neoplasia I

Symbol

men1 Nomenclature History

Previous Names

menin
wu:fc44c03 (1)
zgc:110510

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable Y-form DNA binding activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Predicted to be active in chromatin. Is expressed in several structures, including digestive system; endoderm; head mesenchyme; intermediate cell mass of mesoderm; and nervous system. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Manickam et al., 2000

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With men1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
multiple endocrine neoplasia type 1	Alliance	Multiple endocrine neoplasia 1	131100
		Adrenal adenoma, somatic
		Angiofibroma, somatic
		Carcinoid tumor of lung
		Lipoma, somatic
		Parathyroid adenoma, somatic

Associated With men1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007747	Menin

Domain Details Per Protein

Protein	Length	Menin
UniProtKB:Q9IAA9 InterPro	617

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	men1-201 (1) Ensembl	Ensembl	2,589 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000004029 (1)	Havana	1,093 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000004039 (1)	Havana	2,530 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000004122 (1)	Havana	2,528 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	men1-002 (1) Ensembl	Ensembl	913 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations