Gene

ppm1aa

ID

ZDB-GENE-991102-15

Name

protein phosphatase, Mg2+/Mn2+ dependent, 1Aa

Symbol

ppm1aa Nomenclature History

Previous Names

pp2ca2

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have magnesium-dependent protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of canonical Wnt signaling pathway. Predicted to localize to cytosol and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77022 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppm1aa Human Ortholog

No data available

Associated With ppm1aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000222	PPM-type phosphatase, divalent cation binding
Domain	IPR001932	PPM-type phosphatase-like domain
Domain	IPR012911	Protein serine/threonine phosphatase 2C, C-terminal
Family	IPR015655	Protein phosphatase 2C
Homologous_superfamily	IPR036457	PPM-type phosphatase-like domain superfamily
Homologous_superfamily	IPR036580	Phosphatase 2C, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Phosphatase 2C, C-terminal domain superfamily	PPM-type phosphatase, divalent cation binding	PPM-type phosphatase-like domain	PPM-type phosphatase-like domain superfamily	Protein phosphatase 2C	Protein serine/threonine phosphatase 2C, C-terminal
UniProtKB:Q6NYP6 InterPro	384
UniProtKB:A0A286Y912 InterPro	390
UniProtKB:A0A0R4IYF8 InterPro	382
UniProtKB:A0A8M9Q9J2 InterPro	392

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ppm1aa-201 (1) Ensembl	Ensembl	1,906 nt	Select Tool
mRNA	ppm1aa-202 (1) Ensembl	Ensembl	887 nt	Select Tool
mRNA	ppm1aa-203 (1) Ensembl	Ensembl	1,764 nt	Select Tool ZFIN BLAST
mRNA	ppm1aa-204 (1) Ensembl	Ensembl	1,788 nt	Select Tool ZFIN BLAST
mRNA	ppm1aa-205 (1) Ensembl	Ensembl	5,108 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations