Gene

skia

ID

ZDB-GENE-990715-9

Name

v-ski avian sarcoma viral oncogene homolog a

Symbol

skia Nomenclature History

Previous Names

skiA
id:ibd1250

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have SMAD binding activity and transcription corepressor activity. Involved in several processes, including cardiac conduction; cartilage development; and heart looping. Localizes to nucleus. Used to study craniosynostosis. Is expressed in several structures, including brain; lens; presumptive diencephalon; solid lens vesicle; and tail bud. Orthologous to human SKI (SKI proto-oncogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7157999 (27 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Doyle et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With skia Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
craniosynostosis	Alliance	Shprintzen-Goldberg syndrome	182212

Associated With skia Via Experimental Models

Human Disease	Fish	Conditions	Citations
craniosynostosis	WT + MO2-skia	standard conditions	Doyle et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003380	SKI/SNO/DAC domain
Domain	IPR014890	c-SKI SMAD4-binding domain
Domain	IPR047315	Ski oncogene-like, Dachshund-homology domain
Family	IPR023216	Transcription regulator SKI/SnoN
Homologous_superfamily	IPR009061	Putative DNA-binding domain superfamily
Homologous_superfamily	IPR010919	SAND-like domain superfamily
Homologous_superfamily	IPR037000	Ski-like, DNA-binding domain superfamily