Gene

skib

ID

ZDB-GENE-990715-10

Name

v-ski avian sarcoma viral oncogene homolog b

Symbol

skib Nomenclature History

Previous Names

skiB
fc17g02
wu:fc17g02 (1)
wu:fk79g04

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have SMAD binding activity and transcription corepressor activity. Involved in cartilage development; dorsal/ventral pattern formation; and heart looping. Localizes to nucleus. Used to study craniosynostosis. Is expressed in central nervous system. Orthologous to human SKI (SKI proto-oncogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With skib Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
craniosynostosis	Alliance	Shprintzen-Goldberg syndrome	182212

Associated With skib Via Experimental Models

Human Disease	Fish	Conditions	Citations
craniosynostosis	WT + MO1-skib	standard conditions	Doyle et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003380	SKI/SNO/DAC domain
Domain	IPR014890	c-SKI SMAD4-binding domain
Domain	IPR047315	Ski oncogene-like, Dachshund-homology domain
Family	IPR023216	Transcription regulator SKI/SnoN
Homologous_superfamily	IPR009061	Putative DNA-binding domain superfamily
Homologous_superfamily	IPR010919	SAND-like domain superfamily
Homologous_superfamily	IPR037000	Ski-like, DNA-binding domain superfamily