Gene

dhh

ID

ZDB-GENE-990714-5

Name

desert hedgehog signaling molecule

Symbol

dhh Nomenclature History

Previous Names

sb:eu600

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable metal ion binding activity and peptidase activity. Predicted to act upstream of or within cell-cell signaling; intein-mediated protein splicing; and protein autoprocessing. Predicted to be located in extracellular space and plasma membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu600 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dhh Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
46,XY sex reversal	Alliance	46XY gonadal dysgenesis with minifascicular neuropathy	607080
46,XY sex reversal 7	Alliance	46XY sex reversal 7	233420

Associated With dhh Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000320	Hedgehog, N-terminal signalling domain
Domain	IPR001767	Hedgehog protein, Hint domain
Domain	IPR003586	Hint domain C-terminal
Domain	IPR003587	Hint domain N-terminal
Family	IPR001657	Hedgehog protein
Family	IPR050387	Hedgehog Signaling
Homologous_superfamily	IPR009045	Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Homologous_superfamily	IPR036844	Hint domain superfamily
PTM	IPR006141	Intein N-terminal splicing region