Gene

ephb4a

ID

ZDB-GENE-990415-62

Name

eph receptor B4a

Symbol

ephb4a Nomenclature History

Previous Names

ephB4 (1)
ephB4a
cb646 (1)
rtk5

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in convergent extension; ephrin receptor signaling pathway; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Used to study lymphatic system disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Orthologous to human EPHB4 (EPH receptor B4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

40 figures from 32 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb646 (39 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ephb4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
central conducting lymphatic anomaly	Alliance	Lymphatic malformation 7	617300
		Capillary malformation-arteriovenous malformation 2	618196

Associated With ephb4a Via Experimental Models

Human Disease	Fish	Conditions	Citations
lymphatic system disease	y1Tg + MO4-ephb4a	standard conditions	Li et al., 2018
lymphatic system disease	y1Tg + MO2-ephb4a	standard conditions	Li et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001090	Ephrin receptor ligand binding domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR003961	Fibronectin type III
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR027936	Ephrin receptor, transmembrane domain
Domain	IPR034290	Ephrin type-B receptor 4, ligand binding domain
Domain	IPR037636	EPH-B4, SAM domain
Family	IPR016257	Ephrin receptor type-A /type-B
Family	IPR050449	Ephrin receptor tyrosine kinases
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	EPH-B4, SAM domain	Ephrin receptor ligand binding domain	Ephrin receptor, transmembrane domain	Ephrin receptor type-A /type-B	Ephrin receptor tyrosine kinases	Ephrin type-B receptor 4, ligand binding domain	Fibronectin type III	Fibronectin type III superfamily	Galactose-binding-like domain superfamily	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin-like fold	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:A0A8M9Q872 InterPro	986
UniProtKB:O73875 InterPro	987

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ephb4a-201 (1) Ensembl	Ensembl	2,940 nt	Select Tool ZFIN BLAST
mRNA	ephb4a-202 (1) Ensembl	Ensembl	1,308 nt	Select Tool ZFIN BLAST
mRNA	ephb4a-203 (1) Ensembl	Ensembl	3,056 nt	Select Tool ZFIN BLAST
mRNA	ephb4a-204 (1) Ensembl	Ensembl	2,186 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations