Gene
ephb4a
- ID
- ZDB-GENE-990415-62
- Name
- eph receptor B4a
- Symbol
- ephb4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in convergent extension; ephrin receptor signaling pathway; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Used to study lymphatic system disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Orthologous to human EPHB4 (EPH receptor B4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 40 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb646 (39 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
central conducting lymphatic anomaly | Alliance | Lymphatic malformation 7 | 617300 |
Capillary malformation-arteriovenous malformation 2 | 618196 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
lymphatic system disease | y1Tg + MO4-ephb4a | standard conditions | Li et al., 2018 |
lymphatic system disease | y1Tg + MO2-ephb4a | standard conditions | Li et al., 2018 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001090 | Ephrin receptor ligand binding domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR001660 | Sterile alpha motif domain |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
Domain | IPR027936 | Ephrin receptor, transmembrane domain |
Domain | IPR034290 | Ephrin type-B receptor 4, ligand binding domain |
Domain | IPR037636 | EPH-B4, SAM domain |
Family | IPR016257 | Ephrin receptor type-A /type-B |
Family | IPR050449 | Ephrin receptor tyrosine kinases |
Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
Protein | Length | EPH-B4, SAM domain | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Ephrin type-B receptor 4, ligand binding domain | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class V, conserved site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q872
|
986 | ||||||||||||||||||||
UniProtKB:O73875
|
987 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ephb4a-201
(1)
|
Ensembl | 2,940 nt | ||
mRNA |
ephb4a-202
(1)
|
Ensembl | 1,308 nt | ||
mRNA |
ephb4a-203
(1)
|
Ensembl | 3,056 nt | ||
mRNA |
ephb4a-204
(1)
|
Ensembl | 2,186 nt |
Interactions and Pathways
No data available
Plasmids
No data available