Gene

tcf3a

ID
ZDB-GENE-990415-51
Name
transcription factor 3a
Symbol
tcf3a Nomenclature History
Previous Names
  • tcf3
  • Tcf3b (1)
  • e12
  • E2A (1)
  • zfe12 (1)
  • zgc:113926
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in striated muscle cell development. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Chong et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcf3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agammaglobulinemia 8A Alliance Agammaglobulinemia 8A, autosomal dominant 616941
agammaglobulinemia 8B Alliance Agammaglobulinemia 8B, autosomal recessive 619824
Associated With tcf3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR051098 Neuronal Differentiation E-box Binding Transcription Factors
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Neuronal Differentiation E-box Binding Transcription Factors
UniProtKB:Q90491 583
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tcf3a-201 (1) Ensembl 2,406 nt
mRNA tcf3a-202 (1) Ensembl 763 nt
mRNA tcf3a-203 (1) Ensembl 1,197 nt
ncRNA tcf3a-003 (1) Ensembl 489 nt
ncRNA tcf3a-004 (1) Ensembl 799 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations