Gene

ndr1

ID

ZDB-GENE-990415-256

Name

nodal-related 1

Symbol

ndr1 Nomenclature History

Previous Names

Ndr-1
CHUNP6892
sqt
squint
Znr-2
znr2

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have cytokine activity and type I activin receptor binding activity. Involved in several processes, including animal organ development; positive regulation of fibroblast growth factor receptor signaling pathway; and regionalization. Localizes to protein-containing complex. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in embryonic structure; ovary; posterior lateral line primordium; and unfertilized egg. Orthologous to human NODAL (nodal growth differentiation factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

61 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 17 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ndr1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
situs inversus	Alliance	Heterotaxy, visceral, 5	270100

Associated With ndr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine