Gene

rrm2

ID

ZDB-GENE-990415-25

Name

ribonucleotide reductase M2 polypeptide

Symbol

rrm2 Nomenclature History

Previous Names

r2
cb111 (1)
chunp6884
etID309896.20 (1)

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Description

Predicted to have ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to be involved in deoxyribonucleotide biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in several structures, including nervous system; pectoral fin musculature; pharyngeal arch 3-7 skeleton; proliferative region; and tail bud. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb111 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rrm2 Human Ortholog

No data available

Associated With rrm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR030475	Ribonucleotide reductase small subunit, acitve site
Family	IPR000358	Ribonucleotide reductase small subunit family
Family	IPR033909	Ribonucleotide reductase small subunit
Homologous_superfamily	IPR009078	Ferritin-like superfamily
Homologous_superfamily	IPR012348	Ribonucleotide reductase-like

Domain Details Per Protein

Protein	Length	Ferritin-like superfamily	Ribonucleotide reductase-like	Ribonucleotide reductase small subunit	Ribonucleotide reductase small subunit, acitve site	Ribonucleotide reductase small subunit family
UniProtKB:P79733 InterPro	386
UniProtKB:G3G7U0 InterPro	386

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rrm2-201 (1) Ensembl	Ensembl	2,037 nt	Select Tool
mRNA	rrm2-202 (1) Ensembl	Ensembl	1,023 nt	Select Tool
mRNA	rrm2-203 (1) Ensembl	Ensembl	472 nt	Select Tool
mRNA	rrm2-204 (1) Ensembl	Ensembl	785 nt	Select Tool
mRNA	rrm2-205 (1) Ensembl	Ensembl	906 nt	Select Tool
mRNA	rrm2-206 (1) Ensembl	Ensembl	2,086 nt	Select Tool ZFIN BLAST
mRNA	rrm2-207 (1) Ensembl	Ensembl	2,192 nt	Select Tool ZFIN BLAST
mRNA	rrm2-208 (1) Ensembl	Ensembl	2,292 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations