Gene
tdgf1
- ID
- ZDB-GENE-990415-198
- Name
- teratocarcinoma-derived growth factor 1
- Symbol
- tdgf1 Nomenclature History
- Previous Names
-
- cb85 (1)
- cripto
- oep
- one eyed pinhead
- one-eyed pinhead
- wu:fe01d04
- zgc:109829
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have activin receptor binding activity and nodal binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Localizes to external side of plasma membrane. Used to study neural tube defect. Human ortholog(s) of this gene implicated in colon cancer; congenital heart disease; and visceral heterotaxy. Is expressed in several structures, including EVL; cardiovascular system; diencephalon; ectoderm; and mesoderm. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb85 (38 images)
Wild Type Expression Summary
- All Phenotype Data
- 66 figures from 44 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| neural tube defect | tdgf1m134/m134 | standard conditions | Ma et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cryptic/Cripto, CFC domain | Developmental Signaling Modulators | EGF-like domain |
|---|---|---|---|---|
|
UniProtKB:F1Q691
|
190 | |||
|
UniProtKB:A7MCB2
|
183 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available