Gene
ndr2
- ID
- ZDB-GENE-990415-181
- Name
- nodal-related 2
- Symbol
- ndr2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and type I activin receptor binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Part of protein-containing complex. Is expressed in several structures, including axis; embryonic structure; forebrain; forebrain neural keel; and mesoderm. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 64 figures from 51 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| visceral heterotaxy 5 | Alliance | Heterotaxy, visceral, 5 | 270100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|
|
UniProtKB:P87358
|
501 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available