Gene

max

ID

ZDB-GENE-990415-152

Name

myc associated factor X

Symbol

max Nomenclature History

Previous Names

fa92b04
fb52a04
fb95h11
wu:fa92b04 (1)
wu:fb52a04 (1)
wu:fb95h11 (1)
zmax (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Contributes to transcription regulatory region DNA binding activity. Involved in determination of ventral identity and hemopoiesis. Localizes to SMAD protein complex. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is expressed in central nervous system. Orthologous to human MAX (MYC associated factor X).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55677 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With max Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pheochromocytoma	Alliance	{Pheochromocytoma, susceptibility to}	171300
		Polydactyly-macrocephaly syndrome	620712

Associated With max Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:Q5SPG2 InterPro	151
UniProtKB:P52161 InterPro	165
UniProtKB:A0A8M2B7R2 InterPro	165
UniProtKB:Q6NY29 InterPro	160
UniProtKB:Q803J7 InterPro	156

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	max-201 (1) Ensembl	Ensembl	1,765 nt	Select Tool
mRNA	max-202 (1) Ensembl	Ensembl	996 nt	Select Tool
mRNA	max-204 (1) Ensembl	Ensembl	1,194 nt	Select Tool
mRNA	max-205 (1) Ensembl	Ensembl	911 nt	Select Tool
mRNA	max-206 (1) Ensembl	Ensembl	568 nt	Select Tool
ncRNA	max-002 (1) Ensembl	Ensembl	3,204 nt	Select Tool
ncRNA	max-007 (1) Ensembl	Ensembl	563 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations