Gene
klf1
- ID
- ZDB-GENE-980526-55
- Name
- Kruppel like factor 1 (erythroid)
- Symbol
- klf1 Nomenclature History
- Previous Names
-
- klfd
- zgc:194069
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of gene expression and primitive erythrocyte differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Orthologous to human KLF1 (Kruppel like factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu650 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital dyserythropoietic anemia type IVa | Alliance | Anemia, dyserythropoietic congenital, type IVa | 613673 |
| congenital dyserythropoietic anemia type IVb | Alliance | Anemia, congenital dyserythropoietic, type IVb | 620969 |
| Blood group--Lutheran inhibitor | 111150 | ||
| [Hereditary persistence of fetal hemoglobin] | 613566 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:Q90XE6
|
365 |
Interactions and Pathways
No data available
Plasmids
No data available