Gene

acvr1ba

ID

ZDB-GENE-980526-527

Name

activin A receptor type 1Ba

Symbol

acvr1ba Nomenclature History

Previous Names

acvr1b
taram-a
tarama
alk4 (1)
axis
wu:fb75f01

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have activin binding activity and activin receptor activity, type I. Involved in dorsal/ventral pattern formation; fin regeneration; and formation of primary germ layer. Predicted to localize to activin receptor complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in several structures, including DEL; blastodisc; germ ring; margin; and presumptive shield. Orthologous to human ACVR1B (activin A receptor type 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With acvr1ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pancreatic carcinoma	Alliance	Pancreatic cancer, somatic	260350

Associated With acvr1ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000472	Activin types I and II receptor domain
Domain	IPR000719	Protein kinase domain
Domain	IPR003605	GS domain
Family	IPR000333	Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR045860	Snake toxin-like superfamily