Gene
acvr1ba
- ID
- ZDB-GENE-980526-527
- Name
- activin A receptor type 1Ba
- Symbol
- acvr1ba Nomenclature History
- Previous Names
-
- acvr1b
- taram-a
- tarama
- alk4 (1)
- axis
- wu:fb75f01
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have activin binding activity and activin receptor activity, type I. Involved in dorsal/ventral pattern formation; fin regeneration; and formation of primary germ layer. Predicted to localize to activin receptor complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in several structures, including DEL; blastodisc; germ ring; margin; and presumptive shield. Orthologous to human ACVR1B (activin A receptor type 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pancreatic carcinoma | Alliance | Pancreatic cancer, somatic | 260350 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR003605 | GS domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | GS domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:P79689
|
505 | ||||||||
|
UniProtKB:A0A8M2B949
|
519 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr1ba-201
(1)
|
Ensembl | 3,789 nt | ||
| ncRNA |
acvr1ba-002
(1)
|
Ensembl | 536 nt |
Interactions and Pathways
Plasmids