Gene
wnt4
- ID
- ZDB-GENE-980526-352
- Name
- wingless-type MMTV integration site family, member 4
- Symbol
- wnt4 Nomenclature History
- Previous Names
-
- wnt4a
- ZfWnt4 (1)
- zgc:136737
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have frizzled binding activity. Involved in several processes, including animal organ development; regulation of axon extension involved in axon guidance; and sensory epithelium regeneration. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Is expressed in several structures, including central nervous system; head; neural rod; neural tube; and pleuroperitoneal region. Orthologous to human WNT4 (Wnt family member 4).
- Genome Resources
- Note
-
zebrafish wnt4 is the only ortholog of human WNT4 in zebrafish. Teleost wnt4b is a VGD ohnolog gone missing from humans. Teleosts, gar, coelacanth, and some birds and lizard have orthologs of both wnt4a and wnt4b
- Comparative Information
-
- All Expression Data
- 34 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu648 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mullerian aplasia and hyperandrogenism | Alliance | Mullerian aplasia and hyperandrogenism | 158330 |
| ?SERKAL syndrome | 611812 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-4 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:P47793
|
352 | ||||
|
UniProtKB:Q1RLW9
|
352 |
Interactions and Pathways
No data available
Plasmids