Gene

msx2a

ID

ZDB-GENE-980526-322

Name

muscle segment homeobox 2a

Symbol

msx2a Nomenclature History

Previous Names

msh-A
mshA
msxa (1)
etID309845.14 (1)
zgc:111929

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic morphogenesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Is expressed in several structures, including epidermis; median fin fold; pectoral fin; pectoral fin bud; and vent. Orthologous to human MSX2 (msh homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111929 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Seifinejad et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With msx2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
craniosynostosis 2	Alliance	Craniosynostosis 2	604757
parietal foramina	Alliance	Parietal foramina 1	168500
		Parietal foramina with cleidocranial dysplasia	168550

Associated With msx2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050674	Msh Homeobox Transcriptional Regulators
Homologous_superfamily	IPR009057	Homedomain-like superfamily