Gene

ikzf1

ID

ZDB-GENE-980526-304

Name

IKAROS family zinc finger 1 (Ikaros)

Symbol

ikzf1 Nomenclature History

Previous Names

ikaros (1)
znfn1a1 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and transcription regulatory region DNA binding activity. Involved in B cell differentiation and T cell differentiation in thymus. Predicted to localize to nucleoplasm. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Orthologous to human IKZF1 (IKAROS family zinc finger 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

91 figures from 69 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu522 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ikzf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
common variable immunodeficiency 13	Alliance	Immunodeficiency, common variable, 13	616873

Associated With ikzf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR050589	Ikaros C2H2-type zinc-finger
Family	IPR050758	Zinc finger protein, C2H2-type
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Length	Ikaros C2H2-type zinc-finger	Zinc finger C2H2 superfamily	Zinc finger C2H2-type	Zinc finger protein, C2H2-type
UniProtKB:A0A8M2B3C7 InterPro	641
UniProtKB:A0A8M2B3I1 InterPro	496
UniProtKB:O93581 InterPro	537
UniProtKB:A0A8M3AZ03 InterPro	599
UniProtKB:A0A8M2B2R4 InterPro	588
UniProtKB:A0A8M2B2X4 InterPro	538
UniProtKB:A0A8M2B2N6 InterPro	630

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ikzf1-201 (1) Ensembl	Ensembl	2,301 nt	Select Tool
mRNA	ikzf1-202 (1) Ensembl	Ensembl	1,219 nt	Select Tool
mRNA	ikzf1-203 (1) Ensembl	Ensembl	1,513 nt	Select Tool
mRNA	ikzf1-204 (1) Ensembl	Ensembl	1,639 nt	Select Tool
mRNA	ikzf1-205 (1) Ensembl	Ensembl	1,915 nt	Select Tool
mRNA	ikzf1-206 (1) Ensembl	Ensembl	2,530 nt	Select Tool ZFIN BLAST
mRNA	ikzf1-207 (1) Ensembl	Ensembl	2,254 nt	Select Tool ZFIN BLAST
mRNA	ikzf1-208 (1) Ensembl	Ensembl	1,614 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:Ikaros

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations