Gene
acvr2aa
- ID
- ZDB-GENE-980526-227
- Name
- activin A receptor type 2Aa
- Symbol
- acvr2aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have activin binding activity and activin-activated receptor activity. Involved in cartilage development; hindbrain development; and neural crest cell migration. Predicted to localize to activin receptor complex. Human ortholog(s) of this gene implicated in colon cancer. Is expressed in several structures, including blastoderm; blastomere; gut; oral region; and ovarian follicle. Orthologous to human ACVR2A (activin A receptor type 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Albertson et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Family | IPR017194 | Transforming growth factor-beta receptor, type II |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily | Transforming growth factor-beta receptor, type II |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PS26
|
522 | |||||||
|
UniProtKB:A0A8M9QFD6
|
538 | |||||||
|
UniProtKB:A0A8M2BFL8
|
530 | |||||||
|
UniProtKB:F1QG01
|
514 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr2aa-201
(1)
|
Ensembl | 3,746 nt | ||
| mRNA |
acvr2aa-202
(1)
|
Ensembl | 1,617 nt | ||
| mRNA |
acvr2aa-203
(1)
|
Ensembl | 5,124 nt | ||
| ncRNA |
acvr2aa-002
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available