Gene
ascl1b
- ID
- ZDB-GENE-980526-174
- Name
- achaete-scute family bHLH transcription factor 1b
- Symbol
- ascl1b Nomenclature History
- Previous Names
-
- ashb
- Zash-1b (1)
- zashb
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to contribute to DNA-binding transcription factor activity. Involved in chordate embryonic development; endocrine pancreas development; and hindbrain morphogenesis. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Is expressed in several structures, including central nervous system; neural plate; neural tube; neurons; and posterior neural keel. Orthologous to several human genes including ASCL2 (achaete-scute family bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu104 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR020859 | Roc domain |
| Domain | IPR032171 | C-terminal of Roc (COR) domain |
| Family | IPR050216 | Leucine-rich repeat domain-containing protein |
| Family | IPR050283 | E-box Binding Transcriptional Regulators |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR025875 | Leucine rich repeat 4 |
Domain Details Per Protein
| Protein | Length | C-terminal of Roc (COR) domain | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Leucine-rich repeat | Leucine rich repeat 4 | Leucine-rich repeat domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Myc-type, basic helix-loop-helix (bHLH) domain | P-loop containing nucleoside triphosphate hydrolase | Roc domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90260
|
195 | ||||||||||||
|
UniProtKB:E7F965
|
829 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ascl1b-203
(1)
|
Ensembl | 1,273 nt |
Interactions and Pathways
No data available
Plasmids
No data available