Gene
magi2b
- ID
- ZDB-GENE-141211-6
- Name
- membrane associated guanylate kinase, WW and PDZ domain containing 2b
- Symbol
- magi2b Nomenclature History
- Previous Names
-
- si:ch211-127m7.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Predicted to be involved in receptor clustering and signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Jobst-Schwan et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 15 | Alliance | Nephrotic syndrome, type 15 | 617609 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PDZ domain | PDZ domain 6 | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q467 | InterPro | 1146 | ||||||
| UniProtKB:A0A8M9PEF7 | InterPro | 1145 | ||||||
| UniProtKB:A0A8M9PR83 | InterPro | 697 | ||||||
| UniProtKB:A0A8M9PYZ7 | InterPro | 1171 | ||||||
| UniProtKB:A0A8M9Q8C7 | InterPro | 1152 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
magi2b-201
(1)
|
Ensembl | 4,794 nt | ||
| mRNA |
magi2b-202
(1)
|
Ensembl | 3,449 nt | ||
| mRNA |
magi2b-203
(1)
|
Ensembl | 9,099 nt |
Interactions and Pathways
No data available
Plasmids
No data available