Gene

magi2b

ID

ZDB-GENE-141211-6

Name

membrane associated guanylate kinase, WW and PDZ domain containing 2b

Symbol

magi2b Nomenclature History

Previous Names

si:ch211-127m7.3 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Predicted to be involved in receptor clustering and signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Jobst-Schwan et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With magi2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 15	Alliance	Nephrotic syndrome, type 15	617609

Associated With magi2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q467	InterPro	1146
UniProtKB:A0A8M9PEF7	InterPro	1145
UniProtKB:A0A8M9PR83	InterPro	697
UniProtKB:A0A8M9PYZ7	InterPro	1171
UniProtKB:A0A8M9Q8C7	InterPro	1152
UniProtKB:A0AB32TH84	InterPro	1170
UniProtKB:A0AB32TH86	InterPro	1178
UniProtKB:A0AB32TIM4	InterPro	1154
UniProtKB:A0AB32TIR6	InterPro	1158
UniProtKB:A0AB32TJI5	InterPro	1314
UniProtKB:A0AB32TJZ2	InterPro	1153
UniProtKB:A0AB32TK92	InterPro	1166
UniProtKB:A0AB32TKF1	InterPro	1118
UniProtKB:A0AB32TMV2	InterPro	1160
UniProtKB:A0AB32TPK3	InterPro	1133

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	magi2b-201 (1) Ensembl	Ensembl	4,794 nt	Select Tool ZFIN BLAST
mRNA	magi2b-202 (1) Ensembl	Ensembl	3,449 nt	Select Tool ZFIN BLAST
mRNA	magi2b-203 (1) Ensembl	Ensembl	9,099 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations