Gene
mcc
- ID
- ZDB-GENE-141210-1
- Name
- MCC regulator of WNT signaling pathway
- Symbol
- mcc Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Involved in convergent extension involved in gastrulation. Human ortholog(s) of this gene implicated in colorectal cancer. Is expressed in several structures, including blastomere; digestive system; germ ring; swim bladder; and trunk. Orthologous to human MCC (MCC regulator of WNT signaling pathway).
- Genome Resources
- Note
-
The Ensembl Zv9 mcc entry ENSDARG00000087450 lacks an ATG containing exon. 5'-RACE was performed. [Young et al (2014)] ENSDARG00000090139 contains sequence encoding the the N-terminal of the Mcc protein, which is missing in the ENSDARG00000087450 protein coding sequence.
- Comparative Information
-
- All Expression Data
- 3 figures from Young et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Young et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Harmonin-binding protein USHBP1-like | Harmonin-binding protein USHBP1, PDZ-binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IB06
|
709 | |||||
|
UniProtKB:A0A0R4IV76
|
772 | |||||
|
UniProtKB:A0A8M9QA03
|
789 | |||||
|
UniProtKB:A0A8M9PZA7
|
1013 | |||||
|
UniProtKB:A0A8M9PLQ3
|
680 | |||||
|
UniProtKB:A0A8M9QF20
|
827 | |||||
|
UniProtKB:A0A8M9Q5V7
|
975 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available