Gene
chatb
- ID
- ZDB-GENE-140429-2
- Name
- choline O-acetyltransferase b
- Symbol
- chatb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to enable choline O-acetyltransferase activity. Predicted to be involved in acetylcholine biosynthetic process and neuromuscular synaptic transmission. Predicted to be active in cytoplasm and neuron projection. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase).
- Genome Resources
-
- Alliance (1)
- Gene:103171573 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myasthenic syndrome 6 | Alliance | Myasthenic syndrome, congenital, 6, presynaptic | 254210 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR039551 | Choline/carnitine acyltransferase domain |
| Family | IPR000542 | Acyltransferase ChoActase/COT/CPT |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR042231 | Choline/Carnitine o-acyltransferase, domain 2 |
Domain Details Per Protein
| Protein | Length | Acyltransferase ChoActase/COT/CPT | Chloramphenicol acetyltransferase-like domain superfamily | Choline/carnitine acyltransferase domain | Choline/Carnitine o-acyltransferase, domain 2 |
|---|---|---|---|---|---|
|
UniProtKB:V9Z677
|
635 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance