Gene

prkcab

ID

ZDB-GENE-131121-412

Name

protein kinase C, alpha, b

Symbol

prkcab Nomenclature History

Previous Names

si:ch1073-370j18.1
si:ch73-374l24.1

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm and membrane. Is expressed in brain and retinal inner nuclear layer. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Haug et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkcab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pituitary tumor, invasive

Associated With prkcab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000008	C2 domain
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR020454	Diacylglycerol/phorbol-ester binding
Family	IPR014375	Protein kinase C, alpha/beta/gamma types
Family	IPR050236	Serine/threonine-protein kinases, AGC
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	C1-like domain superfamily	C2 domain	C2 domain superfamily	Diacylglycerol/phorbol-ester binding	Protein kinase, ATP binding site	Protein kinase C, alpha/beta/gamma types	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinases, AGC
UniProtKB:A0A8M3AR84 InterPro	681
UniProtKB:A0A8M3B1B9 InterPro	671

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prkca-203 (1) Ensembl	Ensembl	2,356 nt	Select Tool ZFIN BLAST
mRNA	prkcab-203 (1) Ensembl	Ensembl	2,326 nt	Select Tool ZFIN BLAST
mRNA	si:ch1073-370j18.1-001 (1) Ensembl	Ensembl	350 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations