Gene
kcnj10a
- ID
- ZDB-GENE-130726-1
- Name
- potassium inwardly rectifying channel subfamily J member 10a
- Symbol
- kcnj10a Nomenclature History
- Previous Names
-
- Kir4.1a (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits inward rectifier potassium channel activity. Involved in kidney development; larval locomotory behavior; and swimming. Predicted to localize to integral component of membrane. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Is expressed in several structures, including central nervous system; opercular flap; pleuroperitoneal region; retinal inner nuclear layer; and scale. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 4 | Alliance | Enlarged vestibular aqueduct, digenic | 600791 |
| EAST syndrome | Alliance | SESAME syndrome | 612780 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| EAST syndrome | TL + MO1-kcnj10a | standard conditions | Mahmood et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR003268 | FPotassium channel, inwardly rectifying, Kir1.1 |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
| Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Domain Details Per Protein
| Protein | Length | FPotassium channel, inwardly rectifying, Kir1.1 | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FD27
|
425 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnj10a-201
(1)
|
Ensembl | 1,263 nt | ||
| mRNA |
kcnj10a-202
(1)
|
Ensembl | 1,843 nt |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance