Gene
nek10
- ID
- ZDB-GENE-130530-570
- Name
- NIMA-related kinase 10
- Symbol
- nek10 Nomenclature History
- Previous Names
-
- si:ch211-231m23.2
- zmp:0000000567 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of MAP kinase activity and regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within protein phosphorylation. Is expressed in female organism. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Orthologous to human NEK10 (NIMA related kinase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 44 | Alliance | Ciliary dyskinesia, primary, 44 | 618781 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050660 | NEK Serine/Threonine Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Repeat | IPR000225 | Armadillo |
Domain Details Per Protein
| Protein | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | NEK Serine/Threonine Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Tyrosine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ATV8
|
998 | ||||||||
|
UniProtKB:A0A8M3AJH8
|
1027 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance