Gene

nags

ID

ZDB-GENE-121219-2

Name

N-acetylglutamate synthase

Symbol

nags Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Enables acetyl-CoA:L-glutamate N-acetyltransferase activity and arginine binding activity. Predicted to be involved in arginine biosynthetic process and glutamate metabolic process. Predicted to act upstream of or within urea cycle. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Caldovic et al., 2014

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nags Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
N-acetylglutamate synthase deficiency	Alliance	N-acetylglutamate synthase deficiency	237310

Associated With nags Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006855	Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain
Family	IPR011243	N-acetylglutamate synthase, animal
Homologous_superfamily	IPR016181	Acyl-CoA N-acyltransferase
Homologous_superfamily	IPR036393	Acetylglutamate kinase-like superfamily