Gene
tpp2
- ID
- ZDB-GENE-121214-290
- Name
- tripeptidyl peptidase 2
- Symbol
- tpp2 Nomenclature History
- Previous Names
-
- si:ch73-244f7.4
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable tripeptidyl-peptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol. Is expressed in embryonic structure. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yang et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency 78 with autoimmunity and developmental delay | 619220 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR022229 | Tripeptidyl peptidase II, second Ig-like domain |
| Domain | IPR022232 | Tripeptidyl peptidase II, C-terminal domain, arthropoda |
| Domain | IPR034051 | Tripeptidyl-peptidase II domain |
| Domain | IPR048383 | Tripeptidyl-peptidase II, first Ig-like domain |
| Domain | IPR048384 | Tripeptidyl-peptidase II, galactose-binding domain-like |
| Family | IPR015500 | Peptidase S8, subtilisin-related |
| Family | IPR050131 | Subtilisin-like serine protease |
| Homologous_superfamily | IPR036852 | Peptidase S8/S53 domain superfamily |
| Homologous_superfamily | IPR046939 | Tripeptidyl-peptidase 2, C-terminal domain superfamily |
| Homologous_superfamily | IPR046940 | Tripeptidyl peptidase II, Ig-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site | Subtilisin-like serine protease | Tripeptidyl-peptidase 2, C-terminal domain superfamily | Tripeptidyl peptidase II, C-terminal domain, arthropoda | Tripeptidyl-peptidase II domain | Tripeptidyl-peptidase II, first Ig-like domain | Tripeptidyl-peptidase II, galactose-binding domain-like | Tripeptidyl peptidase II, Ig-like domain superfamily | Tripeptidyl peptidase II, second Ig-like domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BG24
|
1262 | |||||||||||||
|
UniProtKB:R4GDQ0
|
1263 | |||||||||||||
|
UniProtKB:A0A8M1RJV2
|
1249 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance