Gene

adgre5b.3

ID

ZDB-GENE-121214-275

Name

adhesion G protein-coupled receptor E5b, duplicate 3

Symbol

adgre5b.3 Nomenclature History

Previous Names

Cd97d (1)
si:ch73-221f6.7

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to localize to integral component of membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human ADGRE5 (adhesion G protein-coupled receptor E5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Harty et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adgre5b.3 Human Ortholog

No data available

Associated With adgre5b.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR003056	GPCR, family 2, ADGRE2/ADGRE5
Family	IPR050751	Extracellular matrix structural protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Extracellular matrix structural protein	GAIN domain superfamily	GPCR, family 2, ADGRE2/ADGRE5	GPCR, family 2-like, 7TM	GPCR, family 2, secretin-like	GPS motif	Growth factor receptor cysteine-rich domain superfamily	NOTCH1 EGF-like calcium-binding domain
UniProtKB:A0A8M6Z098 InterPro	716
UniProtKB:A0A8M3AUF2 InterPro	421
UniProtKB:A0A8M9Q2I5 InterPro	727
UniProtKB:A0A8M2B737 InterPro	756
UniProtKB:A0A8M9PWR5 InterPro	755
UniProtKB:A0A8M2B717 InterPro	473