Gene
pappaa
- ID
- ZDB-GENE-121113-1
- Name
- pregnancy-associated plasma protein A, pappalysin 1a
- Symbol
- pappaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Involved in several processes, including habituation; insulin-like growth factor receptor signaling pathway; and visual behavior. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in Mauthner neurons; anterior lateral line ganglion; hindbrain interneuron; posterior lateral line ganglion; and statoacoustic (VIII) ganglion. Orthologous to human PAPPA (pappalysin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000800 | Notch domain |
| Domain | IPR006558 | LamG-like jellyroll fold |
| Domain | IPR008754 | Peptidase M43, pregnancy-associated plasma-A |
| Family | IPR043543 | Pappalysin-1/2 |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Repeat | IPR011936 | Myxococcus cysteine-rich repeat |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Fibronectin type III superfamily | LamG-like jellyroll fold | Metallopeptidase, catalytic domain superfamily | Myxococcus cysteine-rich repeat | Notch domain | Pappalysin-1/2 | Peptidase M43, pregnancy-associated plasma-A | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:M1XYM1
|
1629 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pappaa-201
(1)
|
Ensembl | 5,582 nt |
Interactions and Pathways
No data available
Plasmids
No data available