Gene
shroom3
- ID
- ZDB-GENE-120817-1
- Name
- shroom family member 3
- Symbol
- shroom3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within podocyte development and posterior lateral line neuromast development. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in intestine; otic vesicle; posterior lateral line primordium; pronephros; and spinal cord. Used to study chronic kidney disease. Orthologous to human SHROOM3 (shroom family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chronic kidney disease | WT + MO2-shroom3 + MO4-tp53 | standard conditions | Prokop et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apx/Shrm Domain 1 | Apx/Shrm Domain 2 | Shroom family |
|---|---|---|---|---|
|
UniProtKB:K7X477
|
1600 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
shroom3-201
(1)
|
Ensembl | 4,695 nt | ||
| mRNA |
shroom3-202
(1)
|
Ensembl | 899 nt |
Interactions and Pathways
No data available
Plasmids
No data available