Gene

dnhd1

ID

ZDB-GENE-120709-97

Name

dynein heavy chain domain 1

Symbol

dnhd1 Nomenclature History

Previous Names

si:dkey-11m19.5

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Is expressed in brain; pronephric duct; and tail bud. Used to study congenital heart disease.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liu et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Liu et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnhd1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 65	Alliance	Spermatogenic failure 65	619712

Associated With dnhd1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	AB + MO1-dnhd1	standard conditions	Liu et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013602	Dynein heavy chain, linker
Domain	IPR024317	Dynein heavy chain, AAA module D4
Domain	IPR024743	Dynein heavy chain, coiled coil stalk
Domain	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Domain	IPR041466	Dynein heavy chain, AAA 5 extension domain
Family	IPR026983	Dynein heavy chain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR042222	Dynein heavy chain, domain 2, N-terminal
Homologous_superfamily	IPR042228	Dynein heavy chain, linker, subdomain 3
Homologous_superfamily	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain

Domain Details Per Protein

Protein	Additional Resources	Length	Dynein heavy chain	Dynein heavy chain, AAA1 domain, small subdomain	Dynein heavy chain, AAA 5 extension domain	Dynein heavy chain, AAA module D4	Dynein heavy chain, coiled coil stalk	Dynein heavy chain, domain 2, N-terminal	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Dynein heavy chain, linker	Dynein heavy chain, linker, subdomain 3	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9QDX1	InterPro	4503

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:dkey-11m19.5-202 (1) Ensembl	Ensembl		8,010 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations