Gene

vegfba

ID

ZDB-GENE-120510-3

Name

vascular endothelial growth factor Ba

Symbol

vegfba Nomenclature History

Previous Names

si:ch211-245d7.5

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within cerebellum vasculature development and neuron development. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain; head; mid cerebral vein; somite; and trunk. Human ortholog(s) of this gene implicated in myocardial infarction and pulmonary hypertension. Orthologous to human VEGFB (vascular endothelial growth factor B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Jensen et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vegfba Human Ortholog

No data available

Associated With vegfba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023581	Platelet-derived growth factor, conserved site
Domain	IPR000072	PDGF/VEGF domain
Family	IPR050507	Platelet-derived/Vascular endothelial growth factor
Homologous_superfamily	IPR029034	Cystine-knot cytokine
Homologous_superfamily	IPR036841	Vascular endothelial growth factor, heparin-binding domain superfamily

Domain Details Per Protein

Protein	Length	Cystine-knot cytokine	PDGF/VEGF domain	Platelet-derived growth factor, conserved site	Platelet-derived/Vascular endothelial growth factor	Vascular endothelial growth factor, heparin-binding domain superfamily
UniProtKB:E7EZR4 InterPro	246
UniProtKB:A0A8M2B3Z6 InterPro	246

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	vegfba-201 (1) Ensembl	Ensembl		7,435 nt	Select Tool ZFIN BLAST
ncRNA	vegfba-002 (1) Ensembl	Ensembl		671 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations