Gene
trpm6
- ID
- ZDB-GENE-111212-1
- Name
- transient receptor potential cation channel, subfamily M, member 6
- Symbol
- trpm6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable monoatomic cation channel activity. Predicted to be involved in metal ion transport and monoatomic cation transmembrane transport. Predicted to act upstream of or within calcium ion transmembrane transport; protein phosphorylation; and protein tetramerization. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including digestive system; heart; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| intestinal hypomagnesemia 1 | Alliance | Hypomagnesemia 1, intestinal | 602014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004166 | Alpha-type protein kinase, alpha-kinase domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR032415 | TRPM, tetramerisation domain |
| Domain | IPR041491 | TRPM, SLOG domain |
| Family | IPR050927 | Transient receptor potential cation channel M |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR037162 | TRPM, tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-type protein kinase, alpha-kinase domain | Ion transport domain | Protein kinase-like domain superfamily | Transient receptor potential cation channel M | TRPM, SLOG domain | TRPM, tetramerisation domain | TRPM, tetramerisation domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KJE9
|
1530 | |||||||
|
UniProtKB:G4WAZ8
|
1875 | |||||||
|
UniProtKB:A0A8M9Q2T2
|
1875 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available