Gene

agap3

ID

ZDB-GENE-110927-1

Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Symbol

agap3 Nomenclature History

Previous Names

fc25h09
fj34h05
wu:fc25h09
wu:fj34h05

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity and GTPase activity. Predicted to be involved in activation of GTPase activity. Predicted to be active in nucleus. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Xie et al., 2024

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With agap3 Human Ortholog

No data available

Associated With agap3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001164	Arf GTPase activating protein
Domain	IPR001849	Pleckstrin homology domain
Family	IPR001806	Small GTPase
Family	IPR051282	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037278	ARFGAP/RecO-like zinc finger
Homologous_superfamily	IPR038508	ArfGAP domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	ArfGAP domain superfamily	ARFGAP/RecO-like zinc finger	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein	Arf GTPase activating protein	PH-like domain superfamily	Pleckstrin homology domain	P-loop containing nucleoside triphosphate hydrolase	Small GTPase
UniProtKB:A0A8M6YWA1 InterPro	929
UniProtKB:A0A8M3AW63 InterPro	838
UniProtKB:A0A8M3B6U1 InterPro	759
UniProtKB:A0A8M3ANR3 InterPro	800
UniProtKB:A0A8M3AZA0 InterPro	1295

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	agap3-201 (1) Ensembl	Ensembl		3,405 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations