Gene
orai1a
- ID
- ZDB-GENE-110721-1
- Name
- ORAI calcium release-activated calcium modulator 1a
- Symbol
- orai1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to act upstream of or within adaptive immune response. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 9 | Alliance | Immunodeficiency 9 | 612782 |
| tubular aggregate myopathy 2 | Alliance | Myopathy, tubular aggregate, 2 | 615883 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium release-activated calcium channel protein | Orai superfamily |
|---|---|---|---|
|
UniProtKB:A0A0R4IYV8
|
225 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
orai1a-201
(1)
|
Ensembl | 3,251 nt | ||
| mRNA |
orai1a-202
(1)
|
Ensembl | 1,307 nt |
Interactions and Pathways
No data available
Plasmids
No data available